SCHEMBL16240262

SCHEMBL16240262

COc1ccc(Cl)c(OCc2cc(F)c(C(=O)NS(C)(=O)=O)cc2F)c1

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.74
SCN5A Q14524 2/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16239745 0.92 SCN9A (0.74) SCN9ASCN5A
SCHEMBL16239681 0.89 SCN9A (0.72) SCN9ASCN5A
SCHEMBL16239610 0.86 SCN9A (0.74) SCN9ASCN5A
SCHEMBL16239965 0.85 SCN9A (0.76) SCN9ASCN5A
SCHEMBL16239674 0.85 SCN9A (0.76) SCN9ASCN5A
SCHEMBL16239633 0.85 SCN9A (0.88) SCN9ASCN5A
SCHEMBL366583 0.85 SCN9A (1.00) SCN9ASCN5A
SCHEMBL16239773 0.84 SCN9A (0.60) SCN9ASCN5A
SCHEMBL16239881 0.83 SCN9A (0.84) SCN9ASCN5A
SCHEMBL16239723 0.83 SCN9A (0.59) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593428-B1 N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS PFIZER LTD (GB) 2014-11-19 EP disclosed