Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 9/20 | 0.86 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.86 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.86 |
| ▸ | TUBB | P07437 | 1/20 | 0.86 |
| ▸ | YES1 | P07947 | 1/20 | 0.86 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.86 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.86 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.86 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.86 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.86 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.86 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.86 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.86 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.86 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.86 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.86 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.86 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.86 |
| ▸ | MAOB | P27338 | 4/20 | 0.75 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Liquirtigenin SCHEMBL26970367 | 0.93 | CYP19A1 (1.00) | CYP19A1ESR2TUBB4ATUBBYES1 | |
| Liquirtigenin SCHEMBL74552 | 0.93 | CYP19A1 (1.00) | CYP19A1ESR2TUBB4ATUBBYES1 | |
| Liquirtigenin SCHEMBL30352791 | 0.93 | CYP19A1 (1.00) | CYP19A1ESR2TUBB4ATUBBYES1 | |
| Liquirtigenin SCHEMBL1071066 | 0.93 | CYP19A1 (1.00) | CYP19A1ESR2TUBB4ATUBBYES1 | |
| Liquirtigenin SCHEMBL29552383 | 0.93 | CYP19A1 (1.00) | CYP19A1ESR2TUBB4ATUBBYES1 | |
| Liquirtigenin SCHEMBL4649862 | 0.92 | CYP19A1 (0.97) | CYP19A1ESR2TUBB4ATUBBYES1 | |
| Liquirtigenin SCHEMBL718387 | 0.90 | CYP19A1 (0.89) | CYP19A1ESR2TUBB4ATUBBYES1 | |
| SCHEMBL27783109 | 0.88 | CYP19A1 (0.84) | CYP19A1ESR2TUBB4ATUBBYES1 | |
| SCHEMBL14490032 | 0.88 | CYP19A1 (0.84) | CYP19A1ESR2TUBB4ATUBBYES1 | |
| SCHEMBL28625916 | 0.87 | CYP19A1 (0.78) | CYP19A1ESR2TUBB4ATUBBYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757378-B2 | Methods to modulate acute myeloid leukemia stem/progenitor cell expansion and/or differentiation | UNIVERSITE DE MONTREAL (CA) | 2017-09-12 | — | — | US | disclosed |
| US-20140343051-A1 | METHODS TO MODULATE ACUTE MYELOID LEUKEMIA STEM/PROGENITOR CELL EXPANSION AND/OR DIFFERENTIATION | HOPITAL MAISONNEUVE-ROSEMONT (CA) | 2014-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343051-A1 | METHODS TO MODULATE ACUTE MYELOID LEUKEMIA STEM/PROGENITOR CELL EXPANSION AND/OR DIFFERENTIATION | MCL1, AHR, MYADM | CYP19A1 86/4885ESR2 290/4885TUBB4A 2465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.