Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 17/20 | 0.60 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15161422 | 0.86 | MAP4K4 (0.67) | MAP4K4CHEK2MAPK1 | |
| SCHEMBL18595984 | 0.81 | MAP4K4 (0.66) | MAP4K4MAP4K3CHEK2MAPK1 | |
| SCHEMBL15161359 | 0.81 | MAP4K4 (0.71) | MAP4K4 | |
| SCHEMBL15161328 | 0.78 | MAP4K4 (0.61) | MAP4K4CHEK2MAPK1 | |
| SCHEMBL15161394 | 0.76 | MAP4K4 (0.69) | MAP4K4CHEK2 | |
| SCHEMBL15161326 | 0.76 | MAP4K4 (0.69) | MAP4K4CHEK2 | |
| SCHEMBL20968874 | 0.76 | MAP4K4 (0.69) | MAP4K4CHEK2 | |
| SCHEMBL15161325 | 0.76 | MAP4K4 (0.69) | MAP4K4CHEK2 | |
| SCHEMBL15161444 | 0.76 | MAP4K4 (1.00) | MAP4K4MAP4K3 | |
| SCHEMBL15161415 | 0.75 | MAP4K4 (0.73) | MAP4K4MAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2809652-B1 | ISOQUINOLINE AND NAPHTHYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2019-05-15 | — | — | EP | disclosed |
| US-9586956-B2 | Isoquinoline and naphthyridine derivatives | GENENTECH, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20140343036-A1 | ISOQUINOLINE AND NAPHTHYRIDINE DERIVATIVES | GENENTECH, INC. (US) | 2014-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343036-A1 | ISOQUINOLINE AND NAPHTHYRIDINE DERIVATIVES | NQO1, NDUFC2, NDUFV2 | MAP4K4 904/4885MAP4K3 1037/4885CHEK2 1099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.