Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 14/20 | 0.78 |
| ▸ | PLK3 | Q9H4B4 | 7/20 | 0.74 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.74 |
| ▸ | CDK2 | P24941 | 3/20 | 0.74 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.74 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.74 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.74 |
| ▸ | CDK1 | P06493 | 1/20 | 0.74 |
| ▸ | KIT | P10721 | 1/20 | 0.74 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.74 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.74 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.74 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.74 |
| ▸ | FLT4 | P35916 | 1/20 | 0.74 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.74 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.74 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.74 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.74 |
| ▸ | MELK | Q14680 | 1/20 | 0.74 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16240157 | 0.91 | PLK1 (0.76) | PLK1PLK3PLK2CDK2CCNA2 | |
| SCHEMBL3502961 | 0.88 | PLK1 (1.00) | PLK1PLK3PLK2CDK2CCNA2 | |
| Nms-1286937 SCHEMBL30495915 | 0.85 | PLK1 (1.00) | PLK1PLK3PLK2CDK2CCNA2 | |
| SCHEMBL16240083 | 0.83 | PLK1 (0.81) | PLK1PLK3PLK2CDK2CCNA2 | |
| SCHEMBL1560133 | 0.80 | TTK (0.89) | PLK1PLK3PLK2CDK2CCNA2 | |
| SCHEMBL3503538 | 0.79 | PLK1 (0.86) | PLK1PLK3PLK2CDK2CCNA2 | |
| SCHEMBL1559156 | 0.78 | PLK1 (0.80) | PLK1PLK3PLK2CDK2CCNA2 | |
| SCHEMBL12698344 | 0.77 | TTK (0.84) | PLK1PLK3PLK2CDK2CCNA2 | |
| SCHEMBL3503591 | 0.77 | PLK1 (1.00) | PLK1PLK3PLK2CDK2CCNA2 | |
| SCHEMBL13249583 | 0.77 | PLK1 (0.84) | PLK1PLK3PLK2CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125822-B1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2014-11-19 | — | — | EP | claimed |