Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 16/20 | 0.66 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | TEK | Q02763 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16242187 | 0.92 | SCN9A (0.63) | SCN9ASCN5AMAPTMRGPRX4KDR | |
| SCHEMBL16242066 | 0.92 | SCN9A (0.65) | SCN9ASCN5A | |
| SCHEMBL16242206 | 0.91 | SCN9A (0.69) | SCN9ASCN5A | |
| SCHEMBL15055743 | 0.91 | SCN9A (0.79) | SCN9ASCN5AMRGPRX4KDRTEK | |
| SCHEMBL16242252 | 0.91 | SCN9A (0.66) | SCN9ASCN5A | |
| SCHEMBL16242240 | 0.90 | SCN9A (0.59) | SCN9ASCN5A | |
| SCHEMBL16242207 | 0.90 | SCN9A (0.67) | SCN9AKDM4E | |
| SCHEMBL10154434 | 0.89 | SCN9A (0.67) | SCN9ASCN5A | |
| SCHEMBL15054825 | 0.89 | SCN9A (0.81) | SCN9ASCN5AMRGPRX4KDRTEK | |
| SCHEMBL16242042 | 0.89 | SCN9A (0.80) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593433-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-26 | — | — | EP | disclosed |