Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.33 |
| ▸ | ALB | P02768 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | NT5E | P21589 | 1/20 | 0.32 |
| ▸ | POLG | P54098 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ST6GAL1 | P15907 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16243285 | 0.88 | LMNA (0.35) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL2524104 | 0.85 | LMNA (0.35) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL18034250 | 0.85 | LMNA (0.35) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13715903 | 0.85 | — | — | |
| SCHEMBL17426454 | 0.85 | LMNA (0.36) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL17417844 | 0.85 | LMNA (0.36) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL19754061 | 0.84 | LMNA (0.36) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL26882783 | 0.83 | LMNA (0.36) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL14946322 | 0.81 | LMNA (0.38) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL17426455 | 0.81 | LMNA (0.33) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140350080-A1 | INHIBITION OF VIRAL GENE EXPRESSION | UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG (ZA) | 2014-11-27 | — | — | US | disclosed |