SCHEMBL16246714

SCHEMBL16246714

O=Cc1c(-c2ccc(Cl)cc2)nc2ccc(-c3ccccc3)cn12

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 14/20 0.57
TOP2A P11388 1/20 0.57
SLC2A2 P11168 3/20 0.53
ALDH1A1 P00352 2/20 0.51
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29953217 0.93 ALDH1A1 (0.52) SLC2A1TOP2ASLC2A2ALDH1A1NPC1
SCHEMBL1430433 0.90 CYP1A2 (0.52) SLC2A1TOP2AALDH1A1NPC1RAB9A
SCHEMBL7655591 0.87 ALDH1A1 (0.52) SLC2A1ALDH1A1NPC1RAB9A
SCHEMBL15332593 0.82 SLC2A1 (0.51) SLC2A1ALDH1A1NPC1RAB9A
SCHEMBL1431015 0.82 ALDH1A1 (0.59) ALDH1A1NPC1RAB9A
SCHEMBL29951865 0.82 NPC1 (0.52) ALDH1A1NPC1RAB9A
SCHEMBL1430465 0.82 NPC1 (0.74) SLC2A1ALDH1A1NPC1RAB9A
SCHEMBL15330868 0.80 ALDH1A1 (0.63) SLC2A1ALDH1A1NPC1RAB9A
SCHEMBL15332057 0.80 ALDH1A1 (0.46) SLC2A1ALDH1A1NPC1RAB9A
SCHEMBL29956631 0.79 NPC1 (0.51) ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2016-05-05 US disclosed
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2016-05-05 US disclosed
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2016-05-05 US disclosed
EP-3004088-A1 SLC2A TRANSPORTER INHIBITORS Iomet Pharma Ltd. (GB) 2016-04-13 EP disclosed
WO-2014187922-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2014-11-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS SLCO1A2, SLCO2B1, SLCO2A1 SLC2A1 6/4885TOP2A 898/4885SLC2A2 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.