Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5178996 | 0.89 | GAA (0.38) | GAATSHRKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL7139648 | 0.89 | GAA (0.38) | GAATSHRKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL7162007 | 0.84 | HSD17B10 (0.37) | GAATSHRKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL8846408 | 0.83 | KDM4E (0.37) | GAATSHRKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL3227961 | 0.83 | KDM4E (0.37) | GAATSHRKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL10706688 | 0.82 | TSHR (0.40) | GAATSHRKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL787323 | 0.82 | GAA (0.38) | GAATSHRKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL28157114 | 0.80 | KDM4E (0.37) | GAATSHRKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL4591219 | 0.80 | KDM4E (0.40) | GAATSHRKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL28211267 | 0.80 | KDM4E (0.41) | GAATSHRKDM4ESMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2999483-B1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | OHIO STATE INNOVATION FOUNDATION (US) | 2018-10-31 | — | — | EP | disclosed |
| US-20180030094-A1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-01 | — | — | US | disclosed |
| US-9868767-B2 | Chemical synthesis and screening of bicyclic peptide libraries | OHIO STATE INNOVATION FOUNDATION (US) | 2018-01-16 | — | — | US | disclosed |
| US-20160115202-A1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | OHIO STATE INNOVATION FOUNDATION | 2016-04-28 | — | — | US | disclosed |
| EP-2999483-A2 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | Ohio State Innovation Foundation (US) | 2016-03-30 | — | — | EP | disclosed |
| WO-2014190257-A2 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | OHIO STATE INNOVATION FOUNDATION (US) | 2014-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030094-A1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | BAD, VIP, SSB | GAA 2629/4885TSHR 2404/4885KDM4E 4119/4885 |
| US-20160115202-A1 | CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES | BAD, VIP, SSB | GAA 2629/4885TSHR 2404/4885KDM4E 4119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.