Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17221745 | 0.87 | KDM4E (0.50) | KDM4ESMN1; SMN2HPGDPOLBHTT | |
| SCHEMBL16246683 | 0.72 | ALDH1A1 (0.44) | KDM4ESMN1; SMN2MAPTHPGDPOLB | |
| SCHEMBL4068566 | 0.70 | ALDH1A1 (0.35) | KDM4ESMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL16246739 | 0.70 | KDM4E (0.54) | KDM4ESMN1; SMN2HPGDPOLBHTT | |
| SCHEMBL16246665 | 0.68 | KDM4E (0.41) | KDM4ESMN1; SMN2MAPTHPGDHTT | |
| SCHEMBL4770176 | 0.68 | GAA (0.47) | KDM4ESMN1; SMN2HPGDALDH1A1KMT2A | |
| SCHEMBL2011637 | 0.63 | KDM4E (0.47) | KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL31590828 | 0.62 | POLB (0.54) | KDM4EMAPTPOLBALDH1A1PKM | |
| SCHEMBL1564710 | 0.62 | DYRK1A (0.32) | KDM4ESMN1; SMN2MAPTHPGDALDH1A1 | |
| SCHEMBL1564798 | 0.62 | IDO1 (0.33) | ALDH1A1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2999697-A1 | HETEROCYCLIC DERIVATES | Kalvista Pharmaceuticals Limited (GB) | 2016-03-30 | — | — | EP | disclosed |
| WO-2014188211-A1 | HETEROCYCLIC DERIVATES | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2014-11-27 | — | — | WO | disclosed |