Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.73 |
| ▸ | ULK1 | O75385 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16247021 | 0.99 | IGF1R (0.71) | IGF1R | |
| SCHEMBL16247056 | 0.83 | NEK1 (0.72) | IGF1R | |
| SCHEMBL12438047 | 0.83 | IGF1R (1.00) | IGF1R | |
| SCHEMBL16246886 | 0.82 | IGF1R (0.61) | IGF1R | |
| SCHEMBL27239823 | 0.81 | IGF1R (0.63) | IGF1R | |
| SCHEMBL18053315 | 0.79 | IGF1R (0.59) | IGF1R | |
| SCHEMBL16081590 | 0.79 | NEK1 (0.79) | IGF1RULK1 | |
| SCHEMBL12430952 | 0.78 | IGF1R (0.67) | IGF1RULK1 | |
| SCHEMBL11346083 | 0.77 | IGF1R (1.00) | IGF1R | |
| SCHEMBL16081482 | 0.77 | ULK1 (0.60) | IGF1RULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12551482-B2 | Aurora kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-02-17 | — | — | US | disclosed |
| US-20220054489-A1 | AURORA KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-02-24 | — | — | US | disclosed |
| US-11135222-B2 | Aurora kinase inhibitors | THE REGENTS OF THE UNIVERSIITY OF CALIFORNIA (US) | 2021-10-05 | — | — | US | disclosed |
| EP-2999472-B1 | AURORA KINASE INHIBITORS | UNIV CALIFORNIA (US) | 2020-07-22 | — | — | EP | disclosed |
| US-20160250211-A1 | AURORA KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-09-01 | — | — | US | disclosed |
| EP-2999472-A1 | AURORA KINASE INHIBITORS | The Regents of The University of California (US) | 2016-03-30 | — | — | EP | disclosed |
| WO-2014190207-A1 | AURORA KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220054489-A1 | AURORA KINASE INHIBITORS | AURKC, AURKA, AURKB | IGF1R 1224/4885ULK1 426/4885 |
| US-12551482-B2 | Aurora kinase inhibitors | MYC, AURKA, AURKC | IGF1R 855/4885ULK1 1869/4885 |
| US-20160250211-A1 | AURORA KINASE INHIBITORS | AURKC, AURKA, AURKB | IGF1R 1224/4885ULK1 426/4885 |
| US-11135222-B2 | Aurora kinase inhibitors | AURKC, AURKA, AURKB | IGF1R 1224/4885ULK1 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.