Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.30 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.30 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.30 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.30 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16247179 | 1.00 | KDM4E (0.41) | KDM4ETSHRGRIK1GRIA2GRIA4 | |
| SCHEMBL29404888 | 0.84 | KDM4E (0.33) | KDM4ETSHR | |
| SCHEMBL16928563 | 0.81 | KDM4E (0.37) | KDM4ETSHR | |
| SCHEMBL16928561 | 0.76 | HCAR2 (0.43) | KDM4ETSHR | |
| SCHEMBL4946808 | 0.75 | THRB (0.44) | KDM4ETSHRAPEX1 | |
| SCHEMBL20164944 | 0.75 | HCAR2 (0.42) | KDM4ETSHR | |
| SCHEMBL94668 | 0.75 | THRB (0.44) | KDM4ETSHRAPEX1 | |
| SCHEMBL297292 | 0.75 | THRB (0.44) | KDM4ETSHRAPEX1 | |
| SCHEMBL2766997 | 0.74 | TSHR (0.48) | KDM4ETSHR | |
| SCHEMBL2767000 | 0.74 | TSHR (0.48) | KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2999482-A2 | PRODRUGS AND DRUGS | Biogen MA Inc. (US) | 2016-03-30 | — | — | EP | disclosed |
| WO-2014190056-A2 | PRODRUGS AND DRUGS | BIOGEN IDEC MA INC. (US) | 2014-11-27 | — | — | WO | disclosed |