Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19772545 | 0.84 | JAK2 (0.40) | BRD4KCNH2MEN1KMT2ATNK2 | |
| SCHEMBL18805136 | 0.84 | PLAT (0.41) | CDK2BRD4KCNH2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL18788541 | 0.83 | PLAT (0.40) | CDK2BRD4KCNH2MEN1KMT2A | |
| SCHEMBL9894163 | 0.81 | BRD4 (0.34) | BRD4KCNH2MEN1KMT2APLAT | |
| Hydrochloric Acid SCHEMBL16457105 | 0.80 | MEN1 (0.35) | BRD4KCNH2MEN1KMT2APLAT | |
| SCHEMBL15942427 | 0.75 | MEN1 (0.42) | BRD4MEN1KMT2ATNK2PLG | |
| SCHEMBL18805137 | 0.74 | CALCA (0.37) | BRD4KCNH2KMT2APLAT | |
| Hydrochloric Acid SCHEMBL16992353 | 0.73 | MEN1 (0.45) | BRD4MEN1KMT2ATNK2PLG | |
| Hydrochloric Acid SCHEMBL3259989 | 0.73 | MEN1 (0.45) | BRD4MEN1KMT2ATNK2PLG | |
| Hydrochloric Acid SCHEMBL20522326 | 0.73 | CALCA (0.37) | BRD4KCNH2MEN1KMT2APLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160000785-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MERCK PATENT GMBH (DE) | 2016-01-07 | — | — | US | disclosed |
| US-9145392-B2 | Imidazole amines as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2015-09-29 | — | — | US | disclosed |
| US-20140343029-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MERCK PATENT GMBH (DE) | 2014-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160000785-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MAP3K11, MAP3K20, MAP3K19 | CCNE1 530/4885CDK2 89/4885BRD4 320/4885 |
| US-20140343029-A1 | Novel Imidazole Amines as Modulators of Kinase Activity | MAP3K11, MAP3K20, MAP3K19 | CCNE1 530/4885CDK2 89/4885BRD4 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.