Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 10/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29978223 | 0.82 | RAB9A (0.51) | SMN1; SMN2HTTPDE2APDE10ANPC1 | |
| SCHEMBL1624942 | 0.82 | RAB9A (0.51) | SMN1; SMN2HTTPDE2APDE10ANPC1 | |
| SCHEMBL29978531 | 0.79 | CYP11B1 (0.48) | SMN1; SMN2PDE2APDE10ANPC1ALDH1A1 | |
| SCHEMBL28343770 | 0.79 | CYP11B1 (0.48) | SMN1; SMN2PDE2APDE10ANPC1ALDH1A1 | |
| SCHEMBL1624377 | 0.78 | AGPAT2 (0.59) | SMN1; SMN2PDE2APDE10ANPC1ALDH1A1 | |
| SCHEMBL1284166 | 0.77 | PDE2A (0.40) | SMN1; SMN2HTTPDE2APDE10APDE4D | |
| SCHEMBL17896729 | 0.76 | PDE10A (0.46) | SMN1; SMN2PDE2APOLBPDE10AATM | |
| SCHEMBL1624507 | 0.74 | AGPAT2 (0.49) | SMN1; SMN2PDE2APDE10ANPC1ALDH1A1 | |
| SCHEMBL10176223 | 0.71 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBATMKCNH2AOC3 | |
| SCHEMBL10175361 | 0.70 | PDE2A (0.52) | SMN1; SMN2PDE2APOLBPDE10AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835648-B2 | Hedgehog pathway antagonists and therapeutic applications thereof | SIENA BIOTECH S.P.A. (IT) | 2014-09-16 | — | — | US | disclosed |
| US-20120088752-A1 | HEDGEHOG PATHWAY ANTAGONISTS AND THERAPEUTIC APPLICATIONS THEREOF | SIENA BIOTECH S.P.A. (IT) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088752-A1 | HEDGEHOG PATHWAY ANTAGONISTS AND THERAPEUTIC APPLICATIONS THEREOF | SHH, GLI1, SMO | SMN1; SMN2 2687/4885HTT 993/4885PDE2A 2811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.