SCHEMBL16247705

SCHEMBL16247705

CC(=O)CNC(=O)c1c(O)c2cccc(-c3cccc(C)c3)c2oc1=O

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.39
CA9 Q16790 2/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
MAOB P27338 1/20 0.38
GABRG2 P18507 1/20 0.38
GABRB3 P28472 1/20 0.38
GABRA2 P47869 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL933928 0.92 EGLN1 (0.46)
SCHEMBL11934001 0.87 PTPRC (0.41) CA12CA9
SCHEMBL16247701 0.81 HSD17B10 (0.48) CA12CA9ALOX15ALOX12MAOB
SCHEMBL934174 0.81
SCHEMBL11934016 0.80 LDHA (0.41) CA12CA9ALOX15ALOX12MAOB
SCHEMBL933166 0.80
SCHEMBL934353 0.79 EGLN1 (0.46)
SCHEMBL933990 0.79 HIF1A (0.50)
SCHEMBL11934008 0.78 PRKDC (0.44)
SCHEMBL11934011 0.77 PTPRC (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9238637-B2 Stable polymorphic forms of compound as hypoxia mimetics, and uses thereof BEIJING BETTA PHARMACEUTICALS CO., LTD (CN) 2016-01-19 US disclosed
US-20140343137-A1 Stable Polymorphic Forms of Compound as Hypoxia Mimetics, and Uses Thereof BEIJING BETTA PHARMACEUTICALS CO., LTD. (CN) 2014-11-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140343137-A1 Stable Polymorphic Forms of Compound as Hypoxia Mimetics, and Uses Thereof HIF1A, HIF1AN, COXFA4L2 CA12 713/4885CA9 1195/4885ALOX15 258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.