Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 17/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 18/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.56 |
| ▸ | CTSD | P07339 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18342235 | 0.97 | SLC6A2 (0.60) | SLC6A2SLC6A4KCNH2SLC6A3CTSD | |
| SCHEMBL476886 | 0.97 | SLC6A2 (0.60) | SLC6A2SLC6A4KCNH2SLC6A3CTSD | |
| SCHEMBL476885 | 0.97 | SLC6A2 (0.60) | SLC6A2SLC6A4KCNH2SLC6A3CTSD | |
| SCHEMBL5143426 | 0.88 | CTSD (0.55) | SLC6A2SLC6A4KCNH2SLC6A3CTSD | |
| SCHEMBL1623585 | 0.88 | CTSD (0.55) | SLC6A2SLC6A4KCNH2SLC6A3CTSD | |
| SCHEMBL2727813 | 0.88 | CTSD (0.55) | SLC6A2SLC6A4KCNH2SLC6A3CTSD | |
| SCHEMBL3811903 | 0.87 | DCUN1D1 (0.58) | SLC6A2SLC6A4KCNH2SLC6A3CTSD | |
| SCHEMBL4132155 | 0.87 | SLC6A2 (0.60) | SLC6A2SLC6A4KCNH2SLC6A3CTSD | |
| Hydrochloric Acid SCHEMBL21410210 | 0.86 | DCUN1D1 (0.57) | SLC6A2SLC6A4KCNH2SLC6A3CTSD | |
| SCHEMBL1624807 | 0.85 | SLC6A2 (0.55) | SLC6A2SLC6A4KCNH2SLC6A3CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928107-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-04-19 | — | — | US | disclosed |