Sugi Predict

Sugi Predict / Compounds / SCHEMBL16248282

SCHEMBL16248282

SCHEMBL16248282

Cc1c(Br)c(=O)n(C2CCCC2)c2nc(N)ncc12

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CDK4 P11802 9/20 0.54
▸ CCND1 P24385 9/20 0.54
▸ CCND2 P30279 7/20 0.54
▸ CCND3 P30281 7/20 0.54
▸ CCNA2 P20248 3/20 0.54
▸ CDK2 P24941 3/20 0.54
▸ CCNB2 O95067 1/20 0.54
▸ CCNE2 O96020 1/20 0.54
▸ CDK1 P06493 1/20 0.54
▸ FGFR1 P11362 1/20 0.54
▸ CCNB1 P14635 1/20 0.54
▸ FGFR2 P21802 1/20 0.54
▸ FGFR4 P22455 1/20 0.54
▸ FGFR3 P22607 1/20 0.54
▸ CCNE1 P24864 1/20 0.54
▸ CCNA1 P78396 1/20 0.54
▸ CCNB3 Q8WWL7 1/20 0.54
▸ PIK3CA P42336 10/20 0.51
▸ MTOR P42345 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28403699 0.87 CDK4 (0.56) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL13202803 0.85 CDK4 (0.54) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL28404489 0.85 CDK4 (0.55) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL29611418 0.85 CDK4 (0.54) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL4826130 0.83 CDK4 (0.52) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL29507845 0.83 CDK4 (0.52) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL22553519 0.82 CDK4 (0.52) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL4833350 0.82 CDK4 (0.62) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL13202797 0.82 CDK4 (0.52) CDK4CCND1CCND2CCND3CCNA2
SCHEMBL22585653 0.82 CDK4 (0.45) CDK4CCND1CCND2CCND3CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3172214-B1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF SUNSHINE LAKE PHARMA CO LTD (CN) 2020-05-13 — — EP disclosed
US-9828373-B2 2-amino-pyrido[2,3-D]pyrimidin-7(8H)-one derivatives as CDK inhibitors and uses thereof SUNSHINE LAKE PHARMA CO., LTD. (CN) 2017-11-28 — — US disclosed
US-9828373-B2 2-amino-pyrido[2,3-D]pyrimidin-7(8H)-one derivatives as CDK inhibitors and uses thereof SUNSHINE LAKE PHARMA CO., LTD. (CN) 2017-11-28 — — US disclosed
US-20170121323-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2017-05-04 — — US disclosed
US-20170121323-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2017-05-04 — — US disclosed
WO-2016015598-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2016-02-04 — — WO disclosed
WO-2014183520-A1 THIOPHENE MIAZINES DERIVATE, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATION THEREOF 上海恒瑞医药有限公司 (CN) 2014-11-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170121323-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF CDK6, CDK4, CDK7 CDK4 2/4885CCND1 45/4885CCND2 46/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.