Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.63 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.57 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1422839 | 0.84 | NUDT1 (0.64) | JAK2EGLN2NUDT1JAK1 | |
| SCHEMBL13465775 | 0.81 | JAK2 (0.79) | JAK2EGLN2JAK1 | |
| SCHEMBL19659204 | 0.80 | EGLN2 (0.68) | JAK2EGLN2NUDT1JAK1 | |
| SCHEMBL3211261 | 0.78 | JAK2 (0.73) | JAK2 | |
| SCHEMBL3216684 | 0.78 | JAK2 (0.81) | JAK2 | |
| SCHEMBL16248946 | 0.78 | JAK2 (0.79) | JAK2EGLN2JAK1 | |
| SCHEMBL13276213 | 0.78 | JAK2 (1.00) | JAK2 | |
| SCHEMBL3218020 | 0.78 | JAK2 (1.00) | JAK2 | |
| SCHEMBL3214501 | 0.76 | JAK2 (1.00) | JAK2EGLN2JAK1 | |
| SCHEMBL3203884 | 0.76 | JAK2 (1.00) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889673-B2 | Triazolopyridine JAK inhibitor compounds and methods | GENENTECH, INC. (US) | 2014-11-18 | — | — | US | disclosed |