Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.49 |
| ▸ | JAK2 | O60674 | 7/20 | 0.48 |
| ▸ | JAK3 | P52333 | 5/20 | 0.48 |
| ▸ | TYK2 | P29597 | 3/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16249711 | 0.84 | GPR119 (0.46) | JAK1JAK2JAK3TYK2GPR119 | |
| SCHEMBL16249700 | 0.80 | GPR119 (0.44) | JAK1JAK2JAK3TYK2GPR119 | |
| SCHEMBL23029209 | 0.79 | JAK1 (0.75) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL19296935 | 0.78 | JAK1 (0.41) | JAK1JAK2JAK3TYK2USP30 | |
| SCHEMBL21705250 | 0.77 | GPR119 (0.40) | JAK1JAK2JAK3TYK2GPR119 | |
| SCHEMBL12799403 | 0.77 | JAK3 (0.53) | JAK1JAK2JAK3 | |
| SCHEMBL19296934 | 0.76 | JAK3 (0.68) | JAK1JAK2JAK3USP30 | |
| SCHEMBL29863135 | 0.76 | GPR119 (0.48) | GPR119USP30 | |
| SCHEMBL23360071 | 0.76 | GPR119 (0.48) | GPR119USP30 | |
| SCHEMBL23360414 | 0.75 | GPR119 (0.52) | GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889684-B2 | Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-8889684-B2 | Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-18 | — | — | US | disclosed |