Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.66 |
| ▸ | CA9 | Q16790 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.60 |
| ▸ | HPGD | P15428 | 9/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14027239 | 0.74 | KDM4E (0.63) | CA12CA9ALDH1A1KDM4EHPGD | |
| SCHEMBL18095545 | 0.73 | CA9 (0.83) | CA12CA9ALDH1A1KDM4EHPGD | |
| SCHEMBL7860297 | 0.73 | AKR1C3 (0.68) | CA12CA9ALDH1A1KDM4EHPGD | |
| SCHEMBL20554014 | 0.72 | CA12 (0.83) | CA12CA9ALDH1A1KDM4EHPGD | |
| SCHEMBL5646958 | 0.72 | HSD17B3 (0.69) | ALDH1A1KDM4EHPGDHSD17B10NPSR1 | |
| SCHEMBL18095375 | 0.72 | ALDH1A1 (0.72) | CA12CA9ALDH1A1KDM4EHPGD | |
| SCHEMBL18095542 | 0.72 | CA12 (0.71) | CA12CA9ALDH1A1KDM4EHPGD | |
| SCHEMBL29527472 | 0.71 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL5647066 | 0.71 | MAP2K1 (0.58) | ALDH1A1KDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL5648696 | 0.71 | MAP2K1 (0.53) | ALDH1A1KDM4EHPGDSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170003275-A1 | METHOD TO IDENTIFY COMPOUNDS ABLE TO BIND TO THE ROSSMANN FOLD OF C-TERMINAL-BINDING PROTEINS, IDENTIFIED COMPOUNDS AND MEDICAL USES THEREOF | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2017-01-05 | — | — | US | disclosed |
| US-20170003275-A1 | METHOD TO IDENTIFY COMPOUNDS ABLE TO BIND TO THE ROSSMANN FOLD OF C-TERMINAL-BINDING PROTEINS, IDENTIFIED COMPOUNDS AND MEDICAL USES THEREOF | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2017-01-05 | — | — | US | disclosed |
| WO-2014184370-A1 | METHOD TO IDENTIFY COMPOUNDS ABLE TO BIND TO THE ROSSMANN FOLD OF C-TERMINAL-BINDING PROTEINS, IDENTIFIED COMPOUNDS AND MEDICAL USES THEREOF | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2014-11-20 | — | — | WO | disclosed |