Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 10/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TXK | P42681 | 1/20 | 0.37 |
| ▸ | BLK | P51451 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10205209 | 0.93 | ALK (0.47) | FLT4PTK2EGFRALKINSR | |
| SCHEMBL10207086 | 0.93 | EGFR (0.41) | FLT4PTK2EGFRALKINSR | |
| SCHEMBL10205153 | 0.92 | LRRK2 (0.44) | FLT4PTK2EGFRALKINSR | |
| SCHEMBL14331699 | 0.91 | EGFR (0.43) | EGFRALKINSRIGF1RLRRK2 | |
| SCHEMBL16255628 | 0.91 | EGFR (0.39) | FLT4PTK2EGFRALKINSR | |
| SCHEMBL10205156 | 0.90 | EGFR (0.47) | PTK2EGFRALKINSRIGF1R | |
| SCHEMBL10205935 | 0.90 | ALK (0.45) | FLT4PTK2EGFRALKINSR | |
| SCHEMBL10205190 | 0.90 | EGFR (0.51) | FLT4PTK2EGFRALKINSR | |
| SCHEMBL14331737 | 0.89 | EGFR (0.40) | FLT4PTK2EGFRALKINSR | |
| SCHEMBL10207045 | 0.89 | ALK (0.47) | FLT4PTK2EGFRALKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655358-B1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |