Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.39 |
| ▸ | INSR | P06213 | 2/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16255604 | 0.93 | FLT4 (0.41) | EGFRFLT4PTK2ALKINSR | |
| SCHEMBL10205209 | 0.92 | ALK (0.47) | EGFRFLT4PTK2ALKINSR | |
| SCHEMBL10205935 | 0.92 | ALK (0.45) | EGFRFLT4PTK2ALKINSR | |
| SCHEMBL10205190 | 0.92 | EGFR (0.51) | EGFRFLT4PTK2ALKINSR | |
| SCHEMBL10207088 | 0.92 | EGFR (0.51) | EGFRFLT4PTK2ALKINSR | |
| SCHEMBL14331737 | 0.91 | EGFR (0.40) | EGFRFLT4PTK2ALKINSR | |
| SCHEMBL10205156 | 0.90 | EGFR (0.47) | EGFRPTK2ALKINSRIGF1R | |
| SCHEMBL10205180 | 0.90 | EGFR (0.41) | EGFRFLT4PTK2ALKINSR | |
| SCHEMBL10205181 | 0.90 | EGFR (0.45) | EGFRALKINSRIGF1RMET | |
| SCHEMBL10205192 | 0.90 | EGFR (0.42) | EGFRFLT4PTK2ALKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085126-A1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |