Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.47 |
| ▸ | EGFR | P00533 | 10/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16255587 | 0.94 | ALK (0.44) | ALKEGFRFLT4PTK2JAK3 | |
| SCHEMBL10207045 | 0.92 | ALK (0.47) | ALKEGFRFLT4PTK2IGF1R | |
| SCHEMBL16255632 | 0.88 | INSR (0.42) | ALKEGFRFLT4PTK2JAK3 | |
| SCHEMBL10205151 | 0.86 | EGFR (0.44) | ALKEGFRJAK3IGF1RLRRK2 | |
| SCHEMBL10205534 | 0.85 | ALK (0.46) | ALKEGFRFLT4PTK2JAK3 | |
| SCHEMBL10205922 | 0.85 | ALK (0.58) | ALKEGFRJAK3IGF1RLRRK2 | |
| SCHEMBL10205864 | 0.85 | ALK (0.40) | ALKEGFRFLT4PTK2JAK3 | |
| SCHEMBL10205153 | 0.84 | LRRK2 (0.44) | ALKEGFRFLT4PTK2JAK3 | |
| SCHEMBL10205148 | 0.83 | LRRK2 (0.43) | ALKEGFRFLT4PTK2JAK3 | |
| SCHEMBL10205144 | 0.83 | ALK (0.46) | ALKEGFRFLT4PTK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655358-B1 | OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |