Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.66 |
| ▸ | CCR5 | P51681 | 4/20 | 0.66 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12180013 | 1.00 | CCR2 (0.66) | CCR2CCR5JAK2JAK1EGFR | |
| SCHEMBL15083693 | 0.96 | CCR2 (0.65) | CCR2CCR5JAK2JAK1EGFR | |
| SCHEMBL20976574 | 0.96 | CCR2 (0.65) | CCR2CCR5JAK2JAK1EGFR | |
| SCHEMBL15083661 | 0.96 | CCR2 (0.65) | CCR2CCR5JAK2JAK1EGFR | |
| SCHEMBL12180006 | 0.90 | CCR2 (0.79) | CCR2CCR5 | |
| SCHEMBL12179993 | 0.90 | CCR2 (0.79) | CCR2CCR5 | |
| SCHEMBL15083660 | 0.89 | CCR2 (0.83) | CCR2CCR5JAK2JAK1EGFR | |
| SCHEMBL16257572 | 0.89 | CCR2 (0.69) | CCR2CCR5JAK2JAK1EGFR | |
| SCHEMBL15083656 | 0.89 | CCR2 (0.83) | CCR2CCR5JAK2JAK1EGFR | |
| SCHEMBL20976598 | 0.87 | CCR2 (0.64) | CCR2CCR5JAK2JAK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |