Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 20/20 | 0.61 |
| ▸ | CCR5 | P51681 | 8/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257526 | 1.00 | CCR2 (0.61) | CCR2CCR5KCNH2 | |
| SCHEMBL16257560 | 0.91 | CCR2 (0.62) | CCR2CCR5KCNH2 | |
| SCHEMBL16257553 | 0.91 | CCR2 (0.62) | CCR2CCR5KCNH2 | |
| SCHEMBL16257556 | 0.91 | CCR2 (0.61) | CCR2CCR5 | |
| SCHEMBL16257524 | 0.91 | CCR2 (0.61) | CCR2CCR5 | |
| SCHEMBL12180206 | 0.89 | CCR2 (0.74) | CCR2CCR5KCNH2 | |
| SCHEMBL16257543 | 0.89 | CCR2 (0.74) | CCR2CCR5KCNH2 | |
| SCHEMBL12179993 | 0.86 | CCR2 (0.79) | CCR2CCR5KCNH2 | |
| SCHEMBL12180006 | 0.86 | CCR2 (0.79) | CCR2CCR5KCNH2 | |
| SCHEMBL12179989 | 0.84 | CCR2 (0.57) | CCR2CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |