Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.43 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | UBE2M | P61081 | 1/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12180300 | 0.82 | CCR2 (0.52) | CCR2EGFRTRPV4CACNA1BCCRL2 | |
| SCHEMBL14998868 | 0.79 | CCR2 (0.56) | CCR2CCRL2ALDH1A1HPGDCCR5 | |
| SCHEMBL12180253 | 0.78 | CCR2 (0.54) | CCR2CCRL2KDM4EALDH1A1CCR5 | |
| SCHEMBL12184755 | 0.78 | CCR2 (0.85) | CCR2CACNA1BCCRL2NR1I2CCR5 | |
| SCHEMBL16257547 | 0.77 | CNR2 (0.51) | CCR2EGFRCCRL2BRAFPOLB | |
| SCHEMBL12184548 | 0.77 | CCR2 (0.70) | CCR2TRPV4CACNA1BCCRL2NR1I2 | |
| SCHEMBL10232173 | 0.76 | CCR2 (0.54) | CCR2TRPV4CACNA1BCCRL2NR1I2 | |
| SCHEMBL10230513 | 0.76 | CCR2 (0.54) | CCR2TRPV4CACNA1BCCRL2NR1I2 | |
| SCHEMBL16938567 | 0.76 | CCR2 (0.54) | CCR2TRPV4CACNA1BCCRL2NR1I2 | |
| SCHEMBL18924937 | 0.76 | CCR2 (0.59) | CCR2CCRL2CCR5HRH1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |