Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.79 |
| ▸ | CCR5 | P51681 | 6/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16257520 | 0.92 | CCR2 (0.77) | CCR2CCR5KCNH2EGFR | |
| SCHEMBL16257578 | 0.92 | CCR2 (0.78) | CCR2CCR5KCNH2 | |
| SCHEMBL12180206 | 0.90 | CCR2 (0.74) | CCR2CCR5KCNH2EGFR | |
| SCHEMBL16257543 | 0.90 | CCR2 (0.74) | CCR2CCR5KCNH2EGFR | |
| SCHEMBL16257549 | 0.90 | CCR2 (0.73) | CCR2CCR5KCNH2SYK | |
| SCHEMBL16257583 | 0.89 | CCR2 (0.79) | CCR2CCR5KCNH2 | |
| SCHEMBL16257562 | 0.89 | CCR2 (0.79) | CCR2CCR5KCNH2 | |
| SCHEMBL16442358 | 0.89 | CCR2 (0.79) | CCR2CCR5KCNH2 | |
| SCHEMBL14848998 | 0.89 | CCR2 (0.72) | CCR2CCR5KCNH2 | |
| SCHEMBL16442367 | 0.89 | CCR2 (0.62) | CCR2CCR5KCNH2SYKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946218-B2 | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |