Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 19/20 | 0.79 |
| ▸ | CCR5 | P51681 | 4/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12179972 | 0.93 | CCR2 (0.84) | CCR2CCR5KCNH2EGFR | |
| SCHEMBL12179965 | 0.93 | CCR2 (0.84) | CCR2CCR5KCNH2EGFR | |
| SCHEMBL16257559 | 0.89 | CCR2 (1.00) | CCR2CCR5KCNH2EGFR | |
| SCHEMBL16257584 | 0.89 | CCR2 (1.00) | CCR2CCR5KCNH2EGFR | |
| SCHEMBL16257551 | 0.89 | CCR2 (1.00) | CCR2CCR5KCNH2EGFR | |
| SCHEMBL16257517 | 0.89 | CCR2 (1.00) | CCR2CCR5KCNH2EGFR | |
| SCHEMBL16257579 | 0.83 | CCR2 (0.74) | CCR2CCR5KCNH2 | |
| SCHEMBL12180206 | 0.83 | CCR2 (0.74) | CCR2CCR5KCNH2EGFR | |
| SCHEMBL16257543 | 0.83 | CCR2 (0.74) | CCR2CCR5KCNH2EGFR | |
| SCHEMBL16257520 | 0.82 | CCR2 (0.77) | CCR2CCR5KCNH2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569295-B1 | NEW CCR2 RECEPTOR ANTAGONISTS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-11-19 | — | — | EP | disclosed |