Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18621223 | 0.83 | TSHR (0.43) | TSHRACHESMN1; SMN2HPGDERCC5 | |
| SCHEMBL9493573 | 0.83 | TSHR (0.43) | TSHRACHESMN1; SMN2HPGDERCC5 | |
| SCHEMBL9493577 | 0.83 | TSHR (0.43) | TSHRACHESMN1; SMN2HPGDERCC5 | |
| SCHEMBL14950438 | 0.79 | MAOA (0.40) | TSHRACHESMN1; SMN2HPGDERCC5 | |
| SCHEMBL18619735 | 0.79 | MAOA (0.40) | TSHRACHESMN1; SMN2HPGDERCC5 | |
| SCHEMBL15910263 | 0.79 | TSHR (0.39) | TSHRACHESMN1; SMN2HPGDERCC5 | |
| SCHEMBL18458131 | 0.77 | KMT2A (0.41) | TSHRACHESMN1; SMN2HPGDERCC5 | |
| SCHEMBL24832677 | 0.76 | HPGD (0.44) | TSHRACHESMN1; SMN2HPGDERCC5 | |
| SCHEMBL16257947 | 0.76 | HPGD (0.41) | TSHRACHESMN1; SMN2HPGDERCC5 | |
| SCHEMBL20942903 | 0.76 | SMN1; SMN2 (0.41) | TSHRSMN1; SMN2HPGDERCC5FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2014-11-26 | — | — | EP | disclosed |