Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.89 |
| ▸ | EML4 | Q9HC35 | 4/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.59 |
| ▸ | RET | P07949 | 4/20 | 0.59 |
| ▸ | ROS1 | P08922 | 4/20 | 0.59 |
| ▸ | FLT3 | P36888 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16196142 | 1.00 | EGFR (0.89) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207004 | 1.00 | EGFR (0.89) | EGFREML4ALKRETROS1 | |
| Naquotinib SCHEMBL16196078 | 0.94 | EGFR (1.00) | EGFREML4ALKRETROS1 | |
| Naquotinib SCHEMBL29355759 | 0.94 | EGFR (1.00) | EGFREML4ALKRETROS1 | |
| Naquotinib SCHEMBL19921009 | 0.94 | EGFR (1.00) | EGFREML4ALKRETROS1 | |
| Naquotinib SCHEMBL29409491 | 0.92 | EGFR (0.95) | EGFREML4ALKRETROS1 | |
| Naquotinib SCHEMBL18687011 | 0.92 | EGFR (0.95) | EGFREML4ALKRETROS1 | |
| SCHEMBL15134665 | 0.91 | EGFR (0.86) | EGFREML4ALKRETROS1 | |
| SCHEMBL16195821 | 0.91 | EGFR (1.00) | EGFREML4ALKRETROS1 | |
| SCHEMBL16207038 | 0.91 | EGFR (1.00) | EGFREML4ALKRETROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805940-B1 | PYRAZINE CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-11-23 | — | — | EP | disclosed |
| EP-2805940-A1 | PYRAZINE CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2014-11-26 | — | — | EP | disclosed |