Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naquotinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 10/20 | 1.00 |
| ▸ | RET | P07949 | 9/20 | 0.62 |
| ▸ | ROS1 | P08922 | 9/20 | 0.62 |
| ▸ | FLT3 | P36888 | 9/20 | 0.62 |
| ▸ | EML4 | Q9HC35 | 8/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.62 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | BUB1 | O43683 | 1/20 | 0.51 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.51 |
| ▸ | STK16 | O75716 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | LATS1 | O95835 | 1/20 | 0.51 |
| ▸ | SLC25A5 | P05141 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naquotinib SCHEMBL29355759 | 1.00 | EGFR (1.00) | EGFRRETROS1FLT3EML4 | |
| Naquotinib SCHEMBL16196078 | 1.00 | EGFR (1.00) | EGFRRETROS1FLT3EML4 | |
| Naquotinib SCHEMBL29409491 | 0.97 | EGFR (0.95) | EGFRRETROS1FLT3EML4 | |
| Naquotinib SCHEMBL18687011 | 0.97 | EGFR (0.95) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16195821 | 0.96 | EGFR (1.00) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16207133 | 0.96 | EGFR (0.93) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16196142 | 0.94 | EGFR (0.89) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16207004 | 0.94 | EGFR (0.89) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16258225 | 0.94 | EGFR (0.89) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16207170 | 0.93 | EGFR (0.87) | EGFRRETROS1FLT3EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290036-A1 | STABILIZED PHARMACEUTICAL COMPOSITION | Astellas Pharma Inc. (JP) | 2018-03-07 | — | — | EP | claimed |