Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.51 |
| ▸ | RET | P07949 | 4/20 | 0.49 |
| ▸ | ROS1 | P08922 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | BTK | Q06187 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16207192 | 0.90 | EGFR (0.64) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16207091 | 0.85 | EGFR (0.64) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL18251071 | 0.84 | RET (0.55) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16207338 | 0.83 | EGFR (0.65) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16207316 | 0.83 | EGFR (0.65) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16207075 | 0.82 | EGFR (0.66) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL18251097 | 0.80 | EGFR (0.59) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL18251076 | 0.80 | EGFR (0.59) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL18251102 | 0.79 | EGFR (0.61) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL18251096 | 0.78 | EGFR (0.51) | EGFRRETROS1FLT3EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805940-A1 | PYRAZINE CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2014-11-26 | — | — | EP | disclosed |