Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.61 |
| ▸ | RET | P07949 | 10/20 | 0.61 |
| ▸ | ROS1 | P08922 | 10/20 | 0.61 |
| ▸ | FLT3 | P36888 | 10/20 | 0.61 |
| ▸ | EML4 | Q9HC35 | 9/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.61 |
| ▸ | BTK | Q06187 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | BUB1 | O43683 | 1/20 | 0.48 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.48 |
| ▸ | STK16 | O75716 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16195488 | 0.89 | RET (0.76) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16258229 | 0.88 | EGFR (0.60) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL18251078 | 0.86 | EGFR (0.60) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL18251105 | 0.85 | EGFR (0.55) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL18251076 | 0.85 | EGFR (0.59) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16258220 | 0.85 | EGFR (0.57) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL18251071 | 0.85 | RET (0.55) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16207074 | 0.85 | EGFR (0.77) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL18251077 | 0.85 | EGFR (0.55) | EGFRRETROS1FLT3EML4 | |
| SCHEMBL16207092 | 0.84 | EGFR (0.77) | EGFRRETROS1FLT3EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805940-B1 | PYRAZINE CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-11-23 | — | — | EP | disclosed |