Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.33 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.33 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL662261 | 0.88 | LMNA (0.44) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL662361 | 0.85 | LMNA (0.44) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL661613 | 0.76 | CYP1A2 (0.43) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL662728 | 0.74 | LMNA (0.60) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL663100 | 0.74 | CYP1A2 (0.43) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL664476 | 0.72 | CYP1A2 (0.40) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL12423430 | 0.72 | LMNA (0.32) | LMNAGAAHTT | |
| SCHEMBL662235 | 0.70 | CYP1A2 (0.40) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL12424178 | 0.70 | LMNA (0.32) | LMNAGAAHTT | |
| SCHEMBL661677 | 0.70 | LMNA (0.42) | LMNAGAAHTTCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536733-B1 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION | BOEHRINGER INGELHEIM INT (DE) | 2014-11-26 | — | — | EP | disclosed |