Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 17/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16225282 | 0.83 | BRD4 (0.64) | BRD4JAK2BRD2BRD3ERN1 | |
| SCHEMBL16259130 | 0.77 | ERN1 (0.42) | BRD4JAK2BRD2BRD3ERN1 | |
| SCHEMBL17698648 | 0.73 | BRD4 (0.67) | BRD4JAK2BRD2BRD3 | |
| SCHEMBL16225315 | 0.73 | BRD4 (1.00) | BRD4JAK2BRD2BRD3 | |
| SCHEMBL16230878 | 0.73 | BRD4 (0.69) | BRD4JAK2BRD2BRD3 | |
| SCHEMBL16259269 | 0.70 | ATAD2 (0.56) | BRD4BRD2ERN1ATAD2 | |
| SCHEMBL16259213 | 0.70 | ERN1 (0.55) | BRD4BRD2BRD3ERN1ATAD2 | |
| SCHEMBL16226222 | 0.70 | BRD4 (0.68) | BRD4JAK2BRD2BRD3 | |
| SCHEMBL16110369 | 0.70 | BRD4 (0.65) | BRD4JAK2BRD2BRD3 | |
| SCHEMBL16225464 | 0.69 | BRD4 (0.51) | BRD4JAK2BRD2BRD3ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014182929-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. (US) | 2014-11-13 | — | — | WO | disclosed |