SCHEMBL16259151 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	BRD4	O60885	20/20	0.73

▸	TRIM24	O15164	1/20	0.72

▸	TAF1	P21675	1/20	0.72

▸	BRD2	P25440	1/20	0.72

▸	BRPF1	P55201	1/20	0.72

▸	EP300	Q09472	1/20	0.72

▸	BRD3	Q15059	1/20	0.72

▸	BRDT	Q58F21	1/20	0.72

▸	CREBBP	Q92793	1/20	0.72

▸	CECR2	Q9BXF3	1/20	0.72

▸	BRD8	Q9H0E9	1/20	0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL16225532	0.88	BRD4 (0.82)	BRD4TRIM24TAF1BRD2BRPF1
SCHEMBL16225514	0.84	BRD4 (1.00)	BRD4TRIM24TAF1BRD2BRPF1
SCHEMBL16225443	0.84	BRD4 (1.00)	BRD4TRIM24TAF1BRD2BRPF1
SCHEMBL29881459	0.84	BRD4 (1.00)	BRD4TRIM24TAF1BRD2BRPF1
SCHEMBL16225268	0.84	BRD4 (1.00)	BRD4TRIM24TAF1BRD2BRPF1
SCHEMBL16225155	0.84	BRD4 (0.85)	BRD4TRIM24TAF1BRD2BRPF1
SCHEMBL16259152	0.83	BRD4 (0.63)	BRD4TRIM24TAF1BRD2BRPF1
SCHEMBL16225383	0.81	BRD4 (0.88)	BRD4TRIM24TAF1BRD2BRPF1
SCHEMBL16225253	0.81	BRD4 (0.70)	BRD4TRIM24TAF1BRD2BRPF1
SCHEMBL16225573	0.81	BRD4 (0.69)	BRD4TRIM24TAF1BRD2BRPF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2014182929-A1	BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS	GILEAD SCIENCES, INC. (US)	2014-11-13	—	—	WO	disclosed