Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.63 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | TAF1 | P21675 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.46 |
| ▸ | BRD8 | Q9H0E9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16259150 | 0.86 | BRD4 (0.47) | BRD4CREBBP | |
| SCHEMBL16259151 | 0.83 | BRD4 (0.73) | BRD4TRIM24TAF1BRD2BRPF1 | |
| SCHEMBL17698727 | 0.83 | BRD4 (0.79) | BRD4TRIM24TAF1BRD2BRPF1 | |
| SCHEMBL16259244 | 0.82 | BRD4 (0.71) | BRD4TRIM24TAF1BRD2BRPF1 | |
| SCHEMBL17875674 | 0.81 | BRD4 (0.67) | BRD4TRIM24TAF1BRD2BRPF1 | |
| SCHEMBL17698683 | 0.79 | BRD4 (0.65) | BRD4TRIM24TAF1BRD2BRPF1 | |
| SCHEMBL17698788 | 0.79 | BRD4 (0.65) | BRD4TRIM24TAF1BRD2BRPF1 | |
| SCHEMBL17698829 | 0.79 | BRD4 (0.65) | BRD4TRIM24TAF1BRD2BRPF1 | |
| SCHEMBL16225958 | 0.78 | BRD4 (1.00) | BRD4TRIM24TAF1BRD2BRPF1 | |
| SCHEMBL17698757 | 0.78 | BRD4 (0.70) | BRD4TRIM24TAF1BRD2BRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014182929-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. (US) | 2014-11-13 | — | — | WO | disclosed |