Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16231359 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1CYP3A4CYP19A1HDAC6 | |
| SCHEMBL31143640 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1CYP3A4TDP1CYP2C19 | |
| SCHEMBL23619158 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1CYP3A4TDP1CYP2C19 | |
| SCHEMBL7559746 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1CYP3A4TDP1CYP2C19 | |
| SCHEMBL16230666 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2L3MBTL1KCNA5CYP1A2CYP3A4 | |
| SCHEMBL1375896 | 0.82 | CYP19A1 (0.55) | KCNA5CYP1A2CYP3A4LMNACYP11B1 | |
| SCHEMBL18595142 | 0.81 | CYP19A1 (0.45) | SMN1; SMN2L3MBTL1KCNA5CYP1A2CYP3A4 | |
| SCHEMBL30927960 | 0.80 | KCNA5 (0.56) | KCNA5CYP1A2CYP3A4LMNACYP11B1 | |
| SCHEMBL29226694 | 0.80 | KCNA5 (0.56) | KCNA5CYP1A2CYP3A4LMNACYP11B1 | |
| SCHEMBL19013951 | 0.80 | KCNA5 (0.56) | KCNA5CYP1A2CYP3A4LMNACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106568-A1 | COMBINATION OF A JAK INHIBITOR AND A BROMODOMAIN INHIBITOR FOR TREATING CANCER | GILEAD SCIENCES, INC. (US) | 2017-06-22 | — | — | WO | disclosed |
| WO-2014182929-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. (US) | 2014-11-13 | — | — | WO | disclosed |