Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19592701 | 0.84 | SMN1; SMN2 (0.42) | CYP19A1SMN1; SMN2L3MBTL1CHRM2 | |
| SCHEMBL21964811 | 0.84 | CYP19A1 (0.41) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL13330619 | 0.83 | CHRM2 (0.49) | LMNACYP1A2CYP3A4TDP1SMN1; SMN2 | |
| SCHEMBL16259200 | 0.81 | SMN1; SMN2 (0.48) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL21308429 | 0.80 | SMN1; SMN2 (0.45) | CYP19A1LMNACYP1A2SMN1; SMN2L3MBTL1 | |
| SCHEMBL16230666 | 0.79 | SMN1; SMN2 (0.46) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL19879719 | 0.79 | CYP19A1 (0.41) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL21132107 | 0.76 | CYP19A1 (0.52) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL10152872 | 0.75 | CYP19A1 (0.55) | CYP19A1LMNACYP1A2CYP3A4CYP11B1 | |
| SCHEMBL20148780 | 0.74 | KCNA5 (0.50) | CYP19A1CYP3A4SMN1; SMN2L3MBTL1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9585882-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-03-07 | — | — | US | disclosed |