Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 5/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 5/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 5/20 | 1.00 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 5/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 1.00 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 1.00 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 1.00 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 1.00 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.75 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.75 |
| ▸ | KDR | P35968 | 9/20 | 0.73 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.72 |
| ▸ | PLK4 | O00444 | 2/20 | 0.70 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.70 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1626032 | 1.00 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1627105 | 1.00 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1625855 | 1.00 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1627108 | 1.00 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1625859 | 1.00 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1626258 | 0.97 | HDAC3 (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1626254 | 0.97 | HDAC3 (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3942941 | 0.95 | PDGFRB (0.91) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8209114 | 0.95 | PDGFRB (0.91) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1625529 | 0.93 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120322844-A1 | SUBSTITUTED 2-INDOLINONE AS PTK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2012-12-20 | — | — | US | disclosed |
| US-8273785-B2 | Substituted 2-indolinone as PTK inhibitors containing a zinc binding moiety | CURIS, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-20110190366-A1 | SUBSTITUTED 2-INDOLINONE AS PTK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2011-08-04 | — | — | US | disclosed |
| US-7928136-B2 | Inhibitors of protein tyrosine kinase (PTK) receptors; diabetes, an autoimmune disorder, a hyperproliferation disorder, restenosis, fibrosis, psoriasis, von Heppel-Lindau disease, osteoarthritis; 5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-N-hydroxy-2,4-dimethyl-1H-pyrrole-3-carboxamide | CURIS, INC. (US) | 2011-04-19 | — | — | US | disclosed |
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
| US-20080125478-A1 | SUBSTITUTED 2-INDOLINONE AS PTK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190366-A1 | SUBSTITUTED 2-INDOLINONE AS PTK INHIBITORS CONTAINING A ZINC BINDING MOIETY | HDAC2, HDAC1, BAZ2A | PDGFRB 215/4885HDAC3 30/4885HDAC4 14/4885 |
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | HDAC1, HDAC6, HDAC5 | PDGFRB 1790/4885HDAC3 7/4885HDAC4 5/4885 |
| US-20080125478-A1 | SUBSTITUTED 2-INDOLINONE AS PTK INHIBITORS CONTAINING A ZINC BINDING MOIETY | HDAC2, HDAC1, BAZ2A | PDGFRB 215/4885HDAC3 30/4885HDAC4 14/4885 |
| US-20120322844-A1 | SUBSTITUTED 2-INDOLINONE AS PTK INHIBITORS CONTAINING A ZINC BINDING MOIETY | HDAC2, HDAC1, BAZ2A | PDGFRB 215/4885HDAC3 30/4885HDAC4 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.