Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 0.91 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.91 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.91 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.91 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.91 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.91 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.91 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.91 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.91 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.91 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.91 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.91 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.68 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.68 |
| ▸ | KDR | P35968 | 9/20 | 0.66 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.65 |
| ▸ | PLK4 | O00444 | 2/20 | 0.64 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1627105 | 0.95 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1625855 | 0.95 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1626032 | 0.95 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1625859 | 0.95 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1627108 | 0.95 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1626035 | 0.95 | PDGFRB (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3936048 | 0.93 | PDGFRB (0.78) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1626254 | 0.92 | HDAC3 (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1626258 | 0.92 | HDAC3 (1.00) | PDGFRBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3934537 | 0.92 | PDGFRB (0.76) | PDGFRBHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014941-A1 | 3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | SHENZEN CHIPSCREEN BIOSCIENCE, LTD. (CN) | 2009-01-29 | — | — | WO | disclosed |
| WO-2009014941-A1 | 3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | SHENZEN CHIPSCREEN BIOSCIENCE, LTD. (CN) | 2009-01-29 | — | — | WO | disclosed |