Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | IKBKB | O14920 | 2/20 | 0.48 |
| ▸ | CHUK | O15111 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.48 |
| ▸ | PRKACG | P22612 | 1/20 | 0.48 |
| ▸ | PRKACB | P22694 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14794182 | 0.83 | ALDH1A1 (0.46) | KDM4EALDH1A1SMN1; SMN2HPGDIKBKB | |
| SCHEMBL14786196 | 0.80 | IKBKB (0.52) | KDM4EALDH1A1SMN1; SMN2HPGDIKBKB | |
| SCHEMBL14794149 | 0.76 | IKBKB (0.46) | KDM4EALDH1A1SMN1; SMN2HPGDIKBKB | |
| SCHEMBL14794456 | 0.74 | IKBKB (0.47) | KDM4EALDH1A1SMN1; SMN2HPGDIKBKB | |
| SCHEMBL16267119 | 0.72 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2HPGDIKBKB | |
| SCHEMBL14794458 | 0.72 | IKBKB (0.44) | KDM4EALDH1A1SMN1; SMN2HPGDIKBKB | |
| SCHEMBL16273202 | 0.71 | ALDH1A1 (0.42) | KDM4EALDH1A1SMN1; SMN2HPGDIKBKB | |
| SCHEMBL16273198 | 0.68 | CHRM4 (0.50) | KDM4EALDH1A1SMN1; SMN2HPGDIKBKB | |
| SCHEMBL30968548 | 0.68 | KDM4E (0.78) | KDM4EALDH1A1SMN1; SMN2HPGDIKBKB | |
| SCHEMBL14399030 | 0.68 | ALDH1A1 (0.56) | KDM4EALDH1A1SMN1; SMN2HPGDIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9056876-B2 | Substituted 1H-pyrazolo[3′,4′,4,5]thieno[2,3-b]pyridin-3-amine analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2015-06-16 | — | — | US | disclosed |
| US-20140357615-A1 | SUBSTITUTED 1H-PYRAZOLO[3',4',4,5]THIENO[2,3-B]PYRIDIN-3-AMINE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2014-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357615-A1 | SUBSTITUTED 1H-PYRAZOLO[3',4',4,5]THIENO[2,3-B]PYRIDIN-3-AMINE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYCHOLINE RECEPTOR M4 | CHRM4, CHRM3, CHRM5 | KDM4E 1138/4885ALDH1A1 3201/4885SMN1; SMN2 2860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.