Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16234636 | 0.85 | TSHR (0.46) | HPGDTSHRNOTUMKMT2AMEN1 | |
| SCHEMBL12310141 | 0.85 | KMT2A (0.68) | HPGDTSHRNOTUMKMT2AMEN1 | |
| SCHEMBL830741 | 0.85 | KMT2A (0.68) | HPGDTSHRNOTUMKMT2AMEN1 | |
| SCHEMBL31069134 | 0.85 | KMT2A (0.68) | HPGDTSHRNOTUMKMT2AMEN1 | |
| SCHEMBL31002548 | 0.85 | KMT2A (0.68) | HPGDTSHRNOTUMKMT2AMEN1 | |
| SCHEMBL8935823 | 0.85 | KMT2A (0.68) | HPGDTSHRNOTUMKMT2AMEN1 | |
| SCHEMBL7077662 | 0.83 | HPGD (0.54) | HPGDTSHRNOTUMKMT2AMEN1 | |
| SCHEMBL2058985 | 0.83 | HPGD (0.54) | HPGDTSHRNOTUMKMT2AMEN1 | |
| SCHEMBL31212624 | 0.81 | HPGD (0.52) | HPGDTSHRNOTUMKMT2AMEN1 | |
| SCHEMBL21415510 | 0.81 | HPGD (0.56) | HPGDTSHRNOTUMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765770-B2 | Substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as potassium channel modulators | ATAXION, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-8765770-B2 | Substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as potassium channel modulators | ATAXION, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120088780-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2012-04-12 | — | — | US | disclosed |
| US-20120088780-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2012-04-12 | — | — | US | disclosed |
| WO-2010112486-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088780-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | KCNJ2, KCNJ11, KCNH2 | HPGD 2551/4885TSHR 3177/4885NOTUM 3870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.