Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16270460 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBTDP1MAPTMAPK1 | |
| SCHEMBL16270153 | 0.81 | SYK (0.43) | SMN1; SMN2POLBTDP1MAPTMAPK1 | |
| SCHEMBL16270169 | 0.79 | SYK (0.45) | SMN1; SMN2POLBTDP1MAPTMEN1 | |
| SCHEMBL16704549 | 0.78 | HTR2C (0.46) | PKMALDH1A1 | |
| SCHEMBL29191616 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBTDP1MAPTMAPK1 | |
| SCHEMBL27028458 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2POLBTDP1MAPTMAPK1 | |
| SCHEMBL16682536 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2POLBTDP1MAPTMAPK1 | |
| SCHEMBL5112459 | 0.76 | LMNA (0.48) | SMN1; SMN2POLBTDP1MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL18187529 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBTDP1MAPTMAPK1 | |
| SCHEMBL21315725 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBTDP1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150216863-A1 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | UNIV VANDERBILT (US) | 2015-08-06 | — | — | US | disclosed |
| US-20150216863-A1 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | UNIV VANDERBILT (US) | 2015-08-06 | — | — | US | disclosed |
| US-9029366-B2 | Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2015-05-12 | — | — | US | disclosed |
| US-9029366-B2 | Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2015-05-12 | — | — | US | disclosed |
| WO-2013192346-A9 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2014-12-18 | — | — | WO | disclosed |
| US-8901125-B2 | Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2014-12-02 | — | — | US | disclosed |
| US-8901125-B2 | Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2014-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150216863-A1 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | GRM5, GRIK5, GRM3 | SMN1; SMN2 2453/4885POLB 4610/4885TDP1 2368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.