Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIB | P23284 | 3/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | PPID | Q08752 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PPIG | Q13427 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12643950 | 0.88 | PPIB (1.00) | PPIBSMN1; SMN2PPIDPPIG | |
| SCHEMBL15834714 | 0.88 | PPIB (0.62) | PPIBSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL16270317 | 0.85 | PPIB (0.80) | PPIBSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL14617669 | 0.83 | SMN1; SMN2 (0.68) | PPIBSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL16270326 | 0.81 | PPIB (0.54) | PPIBSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL13049648 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2MEN1KMT2ANPC1HPGD | |
| SCHEMBL16270338 | 0.81 | SMN1; SMN2 (0.65) | PPIBSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL14617679 | 0.79 | PPIB (0.58) | PPIBSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL14617667 | 0.79 | SMN1; SMN2 (0.81) | SMN1; SMN2MEN1KMT2ANPC1HPGD | |
| SCHEMBL2730689 | 0.77 | SMN1; SMN2 (0.85) | SMN1; SMN2MEN1KMT2ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8901295-B2 | Inhibitors of cyclophilins and uses thereof | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2014-12-02 | — | — | US | disclosed |