Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | PPID | Q08752 | 2/20 | 0.53 |
| ▸ | PPIB | P23284 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | PPIG | Q13427 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14575947 | 0.89 | PPIB (0.68) | SMN1; SMN2PPIDPPIBKMT2ANPC1 | |
| SCHEMBL14617669 | 0.87 | SMN1; SMN2 (0.68) | SMN1; SMN2PPIDPPIBMEN1KMT2A | |
| SCHEMBL13049648 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2PPIDMEN1KMT2ANPC1 | |
| SCHEMBL16270327 | 0.81 | PPIB (0.79) | SMN1; SMN2PPIDPPIBMEN1KMT2A | |
| SCHEMBL14617667 | 0.78 | SMN1; SMN2 (0.81) | SMN1; SMN2PPIDMEN1KMT2ANPC1 | |
| SCHEMBL12133488 | 0.78 | LTB4R (0.50) | MEN1KMT2ANPC1RAB9ALTB4R | |
| SCHEMBL14617672 | 0.78 | SMN1; SMN2 (0.70) | SMN1; SMN2PPIDMEN1KMT2ANPC1 | |
| SCHEMBL24096202 | 0.77 | HPGD (0.53) | KMT2AHPGDEPHX1ALDH1A1EPHX2 | |
| SCHEMBL15832147 | 0.76 | SMN1; SMN2 (0.67) | SMN1; SMN2PPIDMEN1KMT2ANPC1 | |
| SCHEMBL12643766 | 0.76 | PPIB (0.71) | SMN1; SMN2PPIDPPIBKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8901295-B2 | Inhibitors of cyclophilins and uses thereof | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2014-12-02 | — | — | US | disclosed |