Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.36 |
| ▸ | CBFB | Q13951 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1627480 | 0.94 | SPR (0.61) | SPRGAAMAOBMAPK1MAPT | |
| SCHEMBL1627845 | 0.94 | SPR (0.68) | SPRGAAMAOBMAPK1MAPT | |
| SCHEMBL1626619 | 0.86 | SPR (0.72) | SPRGAAMAOBMAPK1MAPT | |
| SCHEMBL1626308 | 0.86 | SPR (0.72) | SPRGAAMAOBMAPK1MAPT | |
| SCHEMBL1627764 | 0.85 | SPR (0.58) | SPRGAAMAOBMAPK1MAPT | |
| SCHEMBL1626669 | 0.85 | SPR (0.71) | SPRGAAMAOBMAPK1MAPT | |
| SCHEMBL3487292 | 0.84 | SPR (0.43) | SPRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1626660 | 0.82 | SPR (0.62) | SPRGAAMAOBMAPK1MAPT | |
| SCHEMBL1625662 | 0.81 | SPR (0.53) | SPRMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL1626795 | 0.81 | SPR (0.51) | SPRGAAMAOBMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928139-B2 | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof | AMGEN INC. (US) | 2011-04-19 | — | — | US | disclosed |