Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | SDHB | P21912 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5435836 | 0.81 | MAPT (0.50) | PTGDR2MAPTALDH1A1SMN1; SMN2SDHB | |
| SCHEMBL27690837 | 0.80 | MAPT (0.44) | PTGDR2MAPTALDH1A1SMN1; SMN2SDHB | |
| SCHEMBL5430785 | 0.80 | MAPT (0.44) | PTGDR2MAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5439772 | 0.79 | MAPT (0.44) | PTGDR2MAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5437175 | 0.79 | MAPT (0.50) | PTGDR2MAPTSDHBMKNK1MKNK2 | |
| SCHEMBL5184935 | 0.79 | MAPT (0.52) | PTGDR2MAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL27690836 | 0.79 | MAPT (0.45) | PTGDR2MAPTALDH1A1SMN1; SMN2SDHB | |
| SCHEMBL5439379 | 0.77 | MAPT (0.46) | PTGDR2MAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5440937 | 0.77 | MAPT (0.50) | PTGDR2MAPTSMN1; SMN2SDHBMKNK1 | |
| SCHEMBL5430731 | 0.76 | MAPT (0.45) | PTGDR2MAPTALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799646-B1 | NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2014-12-10 | — | — | EP | claimed |