Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SDHB | P21912 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27690836 | 0.93 | MAPT (0.45) | MAPTPTGDR2SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL5435836 | 0.84 | MAPT (0.50) | MAPTPTGDR2SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL5184935 | 0.84 | MAPT (0.52) | MAPTPTGDR2SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL5430785 | 0.83 | MAPT (0.44) | MAPTPTGDR2SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL5437175 | 0.82 | MAPT (0.50) | MAPTPTGDR2MKNK1MKNK2HTR2A | |
| SCHEMBL16275018 | 0.81 | MAPT (0.44) | MAPTPTGDR2ALDH1A1MKNK1MKNK2 | |
| SCHEMBL5439379 | 0.81 | MAPT (0.46) | MAPTPTGDR2SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL5439772 | 0.80 | MAPT (0.44) | MAPTPTGDR2SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL16275012 | 0.80 | PTGDR2 (0.42) | MAPTPTGDR2SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL8264087 | 0.79 | MAPT (0.52) | MAPTPTGDR2SMN1; SMN2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101061098-B | Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors | JANSSEN PHARMACEUTICA NV | 2012-05-23 | — | — | CN | claimed |
| CN-101061098-B | Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors | JANSSEN PHARMACEUTICA NV | 2012-05-23 | — | — | CN | disclosed |
| CN-101061098-A | Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors | JANSSEN PHARMACEUTICA NV (BE) | 2007-10-24 | — | — | CN | disclosed |