Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 3/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14948408 | 0.83 | AADAT (0.46) | TNKSTNKS2PARP1PARP2ADRA1D | |
| SCHEMBL16276276 | 0.83 | CDC7 (0.36) | PARP1ALDH1A1MEN1KMT2A | |
| SCHEMBL16276275 | 0.82 | TNKS (0.39) | TNKSTNKS2PARP1PARP2HTR2C | |
| SCHEMBL14948522 | 0.80 | HTR2C (0.38) | HTR2CTDP1AGTR2FKBP1ASMN1; SMN2 | |
| SCHEMBL14948381 | 0.77 | AADAT (0.47) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL17676483 | 0.77 | AADAT (0.47) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL16276277 | 0.75 | CYP3A4 (0.41) | — | |
| SCHEMBL16276271 | 0.74 | PARP1 (0.35) | PARP1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL18033793 | 0.73 | HCRTR1 (0.37) | ALDH1A1KMT2AKDM4EUSP2TSHR | |
| SCHEMBL10232542 | 0.72 | HTR2C (0.36) | PARP1ADRA1DADRA1AADRA1BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382261-B2 | Substituted quinazolinones as HCV inhibitors | JANSSEN SCIENCES IRELAND UC (IE) | 2016-07-05 | — | — | US | disclosed |
| US-9382261-B2 | Substituted quinazolinones as HCV inhibitors | JANSSEN SCIENCES IRELAND UC (IE) | 2016-07-05 | — | — | US | disclosed |
| US-9126986-B2 | Hetero-bicyclic derivatives as HCV inhibitors | JANSSEN SCIENCES IRELAND UC (IE) | 2015-09-08 | — | — | US | disclosed |
| US-9126986-B2 | Hetero-bicyclic derivatives as HCV inhibitors | JANSSEN SCIENCES IRELAND UC (IE) | 2015-09-08 | — | — | US | disclosed |
| US-20140378485-A1 | QUINAZOLINONE DERIVATIVES AS HCV INHIBITORS | JANSSEN SCIENCES IRELAND UC (IE) | 2014-12-25 | — | — | US | disclosed |
| US-20140378485-A1 | QUINAZOLINONE DERIVATIVES AS HCV INHIBITORS | JANSSEN SCIENCES IRELAND UC (IE) | 2014-12-25 | — | — | US | disclosed |
| US-20140357626-A1 | Hetero-Bicyclic Derivatives As HCV Inhibitors | JANSSEN SCIENCES IRELAND UC (IE) | 2014-12-04 | — | — | US | disclosed |
| US-20140357626-A1 | Hetero-Bicyclic Derivatives As HCV Inhibitors | JANSSEN SCIENCES IRELAND UC (IE) | 2014-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357626-A1 | Hetero-Bicyclic Derivatives As HCV Inhibitors | HAVCR2, ZC3HAV1, SUB1 | TNKS 2817/4885TNKS2 4111/4885PARP1 1160/4885 |
| US-20140378485-A1 | QUINAZOLINONE DERIVATIVES AS HCV INHIBITORS | EIF2AK2, NQO2, IRF3 | TNKS 1463/4885TNKS2 2951/4885PARP1 1160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.