AADAT — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2125876	1.00	19/20
SCHEMBL2132616	1.00	19/20
SCHEMBL2143232	1.00	19/20
SCHEMBL2955903	1.00	19/20
SCHEMBL2126297	0.68	19/20
SCHEMBL2127331	0.68	19/20
SCHEMBL2143190	0.68	19/20
Hydrochloric Acid (SCHEMBL1290357)	0.67	19/20
Hydrochloric Acid (SCHEMBL1239293)	0.51	14/20
SCHEMBL3058822	0.54	8/20
SCHEMBL3225994	0.56	7/20
SCHEMBL3226009	0.56	7/20
SCHEMBL199254	0.48	6/20
SCHEMBL650180	0.44	6/20
SCHEMBL650181	0.44	6/20
SCHEMBL197902	0.41	5/20
SCHEMBL1268608	0.48	4/20
SCHEMBL1269632	0.48	4/20
SCHEMBL893736	0.44	4/20
SCHEMBL366071	0.50	3/20

Clinical trials — most relevant to AADAT by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Apomorphine Pump in Early Stage of Parkinson's Disease (EARLY-PUMP)	PHASE3	COMPLETED
A Study of Adynovate in Previously Treated Chinese Teenagers and Adults With Severe Hemophilia A	PHASE3	COMPLETED
Tryptophan MRI in People With Schizophrenia and Healthy Controls	PHASE2/PHASE3	COMPLETED
The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia	PHASE1/PHASE2	COMPLETED
Serine Supplementation for Obese Subjects With Fatty Liver Disease	PHASE1/PHASE2	COMPLETED
Community-based Clinical Trial With Microbiota-directed Complementary Foods (MDCFs) Made of Locally Available Food Ingredients for the Management of Children With Primary Moderate Acute Malnutrition	PHASE2	UNKNOWN
Suicide Gene Therapy for Donor Lymphocytes Infusion After Allogeneic Hematopoietic Stem Cell Transplantation	PHASE1/PHASE2	COMPLETED
Aminopterin Pharmacokinetic Study In Moderate to Severe Psoriasis	PHASE1	COMPLETED
The Effect of Intravenous L-kynurenine (LKYN) on Cerebral Hemodynamics in Healthy Volunteers	PHASE1	COMPLETED
Diclofenac Dose Response Study	PHASE1	RECRUITING
Dose Escalation Study of BI 2536 BS in Patients With Advanced Solid Tumours With Repeated Administration in Patients With Clinical Benefit	PHASE1	COMPLETED
The Effect of Acute Lysine Administration on α-aminoadipic Acid (Sub-study)	PHASE1	COMPLETED
The Effect of Acute Lysine Administration on α-aminoadipic Acid	PHASE1	COMPLETED
1-Methyl-D-Tryptophan in Treating Patients With Metastatic or Refractory Solid Tumors That Cannot Be Removed By Surgery	PHASE1	COMPLETED
BTK Inhibitor DTRMWXHS-12 in Mantle Cell Lymphoma	PHASE1	COMPLETED
Safety and Efficacy Study of VY-AADC01 for Advanced Parkinson's Disease	PHASE1	COMPLETED
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke	nan	COMPLETED
Lysine Oxidation in Response to Arginine Supplementation	nan	COMPLETED
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes	nan	NOT_YET_RECRUITING
Plasma Molecular Profiling in ALK Inhibitor Resistant NSCLC	nan	COMPLETED
An Assessment of Cognitive Function in Irritable Bowel Syndrome	nan	UNKNOWN
The Effect of Induced Hyperammonaemia on Sleep and Melanopsin-mediated Pupillary Light Response in Patients With Liver Cirrhosis	nan	COMPLETED
Serotonin in Alcoholism	nan	COMPLETED
Effects of Alanine in Patients With Nonalcoholic Steatohepatitis	nan	COMPLETED
Protein Requirements Amongst Male Masters-Level Athletes Following a Cycling Exercise Bout as Determined by the Indicator Amino Acid Oxidation Technique	nan	RECRUITING
Assesment of Vitamin B6 Level in Patients With Major Depressive Disorder	nan	UNKNOWN
Tryptophan Metabolism in Healthy Young Adults	nan	COMPLETED
Tryptophan Metabolism in Human Brain Tumors	nan	COMPLETED
Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol	nan	COMPLETED
PANDA: PKU Amino Acid Evaluation	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a AADAT binder may also engage these)

Protein	Name	Similarity
Q5E9N4	—	1.000	Q5E9N4 →
Q64602	—	0.994	Q64602 →
Q9WVM8	—	0.987	Q9WVM8 →
Q7T3E5	—	0.980	Q7T3E5 →
Q71RI9	—	0.977	Q71RI9 →
Q58FK9	—	0.976	Q58FK9 →
Q0P5G4	—	0.975	Q0P5G4 →
Q8BTY1	—	0.972	Q8BTY1 →
KYAT1	Kynurenine--oxoglutarate transaminase 1	0.972	landscape →
Q17CS8	—	0.971	Q17CS8 →
KYAT3	Kynurenine--oxoglutarate transaminase 3	0.971	landscape →
Q08415	—	0.969	Q08415 →
Q9STR4	—	0.965	Q9STR4 →
P28734	—	0.963	P28734 →
P13221	—	0.962	P13221 →
Q9SIE1	—	0.961	Q9SIE1 →
P23599	—	0.961	P23599 →
A5A6K8	—	0.961	A5A6K8 →
GOT1	Aspartate aminotransferase, cytoplasmic	0.961	landscape →
P37833	—	0.960	P37833 →
Q07262	—	0.959	Q07262 →
O88813	—	0.959	O88813 →
P55216	—	0.958	P55216 →
Q00379	—	0.958	Q00379 →
P37821	—	0.958	P37821 →
P18485	—	0.958	P18485 →
Q58CZ9	—	0.958	Q58CZ9 →
O14209	—	0.958	O14209 →
Q5R691	—	0.957	Q5R691 →
Q8JZR0	—	0.957	Q8JZR0 →